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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
20.3
Human Site:
S289
Identified Species:
34.36
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
S289
K
R
I
T
I
T
E
S
N
M
K
S
R
Y
T
Chimpanzee
Pan troglodytes
XP_521839
646
71607
S289
K
R
I
T
I
T
E
S
N
M
K
S
R
Y
T
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
S244
C
V
Y
A
I
K
R
S
M
K
T
F
A
E
L
Dog
Lupus familis
XP_534051
887
95991
S530
K
R
I
T
I
T
E
S
N
M
K
S
R
Y
T
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
S288
K
R
I
T
I
T
E
S
N
M
K
S
R
Y
T
Rat
Rattus norvegicus
Q63802
646
71478
N289
R
I
T
I
T
E
S
N
M
K
S
R
Y
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
G248
K
C
V
K
R
L
D
G
C
I
Y
A
I
K
R
Chicken
Gallus gallus
NP_001026352
641
70947
S285
K
R
I
T
I
T
E
S
N
M
K
S
R
Y
A
Frog
Xenopus laevis
P47817
555
61670
R230
S
V
F
K
C
V
K
R
L
D
G
C
F
Y
A
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
F276
E
K
N
G
S
G
Q
F
G
S
V
F
K
C
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
S277
S
K
K
P
V
A
G
S
S
F
E
K
R
A
L
Honey Bee
Apis mellifera
XP_624069
589
66032
I265
T
Y
A
I
K
K
S
I
K
P
V
A
G
S
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
G284
E
A
E
F
V
E
V
G
K
V
G
S
G
E
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
D176
D
T
D
E
V
M
G
D
K
L
Q
A
N
Q
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
13.3
100
N.A.
100
6.6
N.A.
6.6
93.3
6.6
0
N.A.
13.3
0
N.A.
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
100
20
N.A.
33.3
93.3
13.3
26.6
N.A.
40
6.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
0
8
0
0
0
0
0
22
8
8
15
% A
% Cys:
8
8
0
0
8
0
0
0
8
0
0
8
0
8
0
% C
% Asp:
8
0
8
0
0
0
8
8
0
8
0
0
0
0
0
% D
% Glu:
15
0
8
8
0
15
36
0
0
0
8
0
0
15
0
% E
% Phe:
0
0
8
8
0
0
0
8
0
8
0
15
8
0
8
% F
% Gly:
0
0
0
8
0
8
15
15
8
0
15
0
15
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
36
15
43
0
0
8
0
8
0
0
8
0
8
% I
% Lys:
43
15
8
15
8
15
8
0
22
15
36
8
8
8
0
% K
% Leu:
0
0
0
0
0
8
0
0
8
8
0
0
0
0
15
% L
% Met:
0
0
0
0
0
8
0
0
15
36
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
8
36
0
0
0
8
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
8
0
0
8
0
% Q
% Arg:
8
36
0
0
8
0
8
8
0
0
0
8
43
0
8
% R
% Ser:
15
0
0
0
8
0
15
50
8
8
8
43
0
8
0
% S
% Thr:
8
8
8
36
8
36
0
0
0
0
8
0
0
8
43
% T
% Val:
0
15
8
0
22
8
8
0
0
8
15
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
0
0
0
0
0
0
0
8
0
8
43
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _